Table 2 Cellular distribution of heparan sulphate proteoglycans in normal (n = 12), early rheumatoid (n = 8), longstanding rheumatoid (n = 13),osteoarthritis (n = 6) and psoriatic (n = 7) synovium
TissueSyndecan-1Syndecan-2Syndecan-3Syndecan-4Glypican-1Glypican-3Glypican-4
Normal
Lining layer++
Sublining:
    Fibroblasts+
    Mononuclear infiltrates
    Macrophages+
    Endothelium+++
    Smooth muscle cells++
    Pericytes++
Early rheumatoidND
Lining layer++++++
Sublining:
    Fibroblasts+
    Mononuclear infiltrates+++
    Macrophages++
    Endothelium++++++
    Smooth muscle cells+++
    Pericytes++
Longstanding rheumatoid
Lining layer++++
Sublining:
    Fibroblasts+
    Mononuclear infiltrates++++
    Macrophages++
    Endothelium++++++
    Smooth muscle cells+++
    Pericytes+++
Osteoarthritis
Lining layer++
Sublining:
    Fibroblasts+
    Mononuclear infiltrates+
    Macrophages++
    Endothelium+++++
    Smooth muscle cells+++
    Pericytes++
Psoriatic
Lining layer++++++
Sublining:
    Fibroblasts+
    Mononuclear infiltrates++++
    Macrophages++
    Endothelium++++++
    Smooth muscle cells++-+
    Pericytes+++
  • Immunoreactivity of cells: − no staining; + weak staining; ++ strong staining; +++ very strong staining.

  • ND, not determined.