Table 3 Patient acceptable symptom state (PASS) cut-off points for composite indices and health status measures after 12, 24 and 52 weeks' treatment (75th centile approach)
Measure12 Weeks (n = 591)24 Weeks (n = 592)52 Weeks (n = 573)
Composite indices
    DAS284.214.053.90
    SDAI17.715.814.7
    CDAI16.414.413.3
    PAS3.463.403.40
Global scales
    Investigator global VAS26.022.021.0
    Patient global VAS36.035.037.0
    Joint pain VAS34.034.034.0
    Fatigue VAS50.050.050.0
Functional measures
    MHAQ1.501.501.50
    HAQ1.041.041.04
SF-36
    Physical50.050.050.0
    Bodily pain41.041.041.0
    General health45.047.047.0
    Vitality40.040.040.0
    Social function75.062.575.0
    Mental68.072.068.0
  • CDAI, Clinical Disease Activity Index; DAS28, 28-joint Disease Activity Score; HAQ, Health Assessment Questionnaire; MHAQ, modified Health Assessment Questionnaire; PAS, Patient Activity Scale; SDAI, Simplified Disease Activity Index; SF-36, Short Form-36; VAS, visual analogue scale (mm).