Table 2 Patient acceptable symptom state (PASS) cut-off points for disease activity and health status measures after 24 weeks’ treatment
Measure75% (n = 945)ROC (n = 1496)Area under the curveSensitivity/specificity
Composite indices
    DAS284.113.930.7572/67
    SDAI16.215.30.7673/67
    CDAI14.713.00.7671/69
    PAS3.563.280.8271/79
Global scales
    Investigator global VAS23.019.00.7367/69
    Patient global VAS37.036.00.8374/75
    Joint pain VAS35.029.00.8068/76
    Fatigue VAS50.042.00.7168/66
Functional measures
    MHAQ1.501.430.7564/70
    HAQ1.040.940.7568/70
SF-36
    Physical50.055.60.7469/69
    Bodily pain41.042.00.8065/81
    General health47.047.00.7676/65
    Vitality40.045.00.7674/76
    Social function62.575.00.7274/60
    Mental72.080.00.6961/68
  • CDAI, Clinical Disease Activity Index; DAS28, 28-joint Disease Activity Score; HAQ, Health Assessment Questionnaire; MHAQ, modified Health Assessment Questionnaire; PAS, Patient Activity Scale; ROC, receiver operating characteristic; SDAI, Simplified Disease Activity Index; SF-36, Short Form-36; VAS, visual analogue scale (mm).