Table 3 Sensitivity to change in total score for SENS compared with gold standard SHS based on SDC and ROC based cut-offs
Reader (n)Cut-off levelSensitivity %Specificity %κ
SHSSENS
1 (n = 251)SDC = 4.98SDC = 2.2865.497.30.66
2*1*88.781.50.61
2 (n = 189)SDC = 4.98SDC = 2.2845.099.40.57
3*1*82.485.80.58

  • SHS, Sharp–van der Heijde Score; SENS, Simplified Erosion Narrowing Score; SDC, smallest detectable change; n, number of patients.

  • *ROC-based reader specific cut-offs.