Patient reported outcome | Treatment difference* (95% CI) | Relative per cent improvement† | Standardised response mean† (95% CI) | Relative efficiency‡ |
Tender joint count | −8.1 (−11.1 to −5.1) | 25 | 0.57 (0.35 to 0.78) | – |
Swollen joint count | −4.6 (−6.9 to −2.4) | 21 | 0.43 (0.22 to 0.64) | 0.57 |
Patient global assessment | −16.7 (−22.8 to −10.7) | 24 | 0.58 (0.37 to 0.80) | 1.04 |
Physician global assessment | −17.5 (−22.6 to −12.4) | 26 | 0.72 (0.51 to 0.94) | 1.60 |
Pain assessment | −20.0 (−26.2 to −13.7) | 28 | 0.67 (0.46 to 0.89) | 1.38 |
HAQ | −0.33 (−0.44 to −0.22) | 18 | 0.63 (0.42 to 0.85) | 1.22 |
C reactive protein | −22.6 (−31.2 to −13.9) | 52 | 0.55 (0.34 to 0.76) | 0.93 |
ESR | −19.1 (−25.2 to −13.1) | 38 | 0.77 (0.52 to 1.02) | 1.82 |
Activity limitation | −5.9 (−8.4 to −3.4) | 35 | 0.51 (0.29 to 0.29) | 0.80 |
Fatigue | −16.8 (−22.8 to −10.8) | 23 | 0.59 (0.38 to 0.81) | 1.07 |
Sleep quality | −7.6 (−11.1 to −4.1) | 16 | 0.46 (0.24 to 0.67) | 0.65 |
SF-36 Physical functioning | 4.1 (2.0 to 6.2) | 16 | 0.43 (0.21 to 0.64) | 0.57 |
SF-36 Role-physical | 6.0 (3.7 to 8.2) | 19 | 0.57 (0.35 to 0.78) | 1.00 |
SF-36 Bodily pain | 6.5 (4.5 to 8.6) | 21 | 0.68 (0.46 to 0.90) | 1.42 |
SF-36 General health | 3.2 (1.5 to 5.0) | 9 | 0.42 (0.20 to 0.63) | 0.54 |
SF-36 Vitality | 5.6 (3.4 to 7.9) | 16 | 0.55 (0.33 to 0.76) | 0.93 |
SF-36 Social functioning | 5.2 (2.7 to 7.7) | 16 | 0.44 (0.22 to 0.65) | 0.60 |
SF-36 Role-emotional | 4.3 (0.9 to 7.6) | 12 | 0.28 (0.07 to 0.49) | 0.24 |
SF-36 Mental health | 3.5 (1.4 to 5.6) | 8 | 0.35 (0.14 to 0.56) | 0.38 |
SF-36 Physical component | 5.5 (3.6 to 7.4) | 20 | 0.62 (0.40 to 0.83) | 1.18 |
SF-36 Mental component | 3.7 (1.3 to 6.1) | 9 | 0.33 (0.12 to 0.54) | 0.34 |
*Treatment difference: ma−mc, where ma = the mean change score from baseline in the abatacept group, and mc = corresponding values for the control group.
†See appendix for derivation.
‡Relative efficiency: (SRM of outcome)2 / (SRM of tender joint count)2.
CI, confidence interval; ESR, erythrocyte sedimentation rate; HAQ, health assessment questionnaire; SF-36, short form 36 item health survey; SRM, standardised response mean.