Table 3 Number of studies reporting one or more significant association grouped by total sample size and disease outcome measure, with additional characteristics of analysis and reporting (number of studies: applying a correction for multiple testing; with reliance on subgroup analysis; and with missing details or results; see text for details)
Disease outcome measureTotal
PrevalenceSeverity
Total sample size <150
Total number of studies11213
Number of studies with:
    ⩾1 significant association729
    Correction for type I error rate*1/4NA1/4
    Main association(s) in subgroup analysis505
    Missing details729
Total sample size ⩾150
Total number of studies68977
Number of studies with:
    ⩾1 significant association52759
    Correction for type I error rate*6/252/48/29
    Main association(s) in subgroup analysis9514
    Missing details42547
  • *Proportion of studies applying a correction among those that reported ⩾ significant association and tested for association at >1 locus.

  • NA, not applicable.