Table 3 Frequency of remission parameters at 5 years after methotrexate start by category of American College of Rheumatology (ACR) Pediatric response at 6 months
Non-responders (n = 42)30% Responders (n = 24)50% Responders (n = 26)70% Responders (n = 33)p Value
Physician global assessment = 012/42 (28.6)5/24 (20.8)10/26 (38.5)18/33 (54.5)0.04*
Active joint count = 013/42 (31.0)4/24 (16.7)7/26 (26.9)18/33 (54.5)0.02†
Restricted joint count = 019/42 (45.2)8/24 (33.3)8/26 (30.8)18/33 (54.5)0.22
C-HAQ score = 011/24 (45.8)9/18 (50.0)10/18 (55.6)19/25 (76.0)0.15
ESR <20 mm/h27/42 (64.3)10/24 (41.7)18/26 (69.2)26/33 (78.8)0.03†
Inactive disease‡12/42 (28.6)4/24 (16.7)7/26 (26.9)18/33 (54.5)0.014†
  • Values are number positive/number tested (%).

  • *Post-hoc analysis: p = 0.06.

  • †The percentage of patients with active joint count = 0, erythrocyte sedimentation rate <20 mm/h, and inactive disease is higher in 70% responders than in 30% responders (all p values = 0.02).

  • ‡Defined according to CA Wallace et al.23

  • C-HAQ, Childhood Health Assessment Questionaire; ESR, erythrocyte sedimentation rate.