Table 2 Therapeutic interventions from 6 months to 5 years after methotrexate start by category of American College of Rheumatology (ACR) Pediatric response at 6 months
Non-responders (n = 42)30% Responders (n = 24)50% Responders (n = 26)70% Responders (n = 33)
Increase⩾50% in methotrexate dose17 (40.5)10 (41.7)3 (11.5)5 (15.2)
Start or dosage increase of prednisone13 (31.0)4 (16.7)3 (11.5)3 (9.1)
Introduction of a further second line agent8 (19.0)4 (16.7)4 (15.4)1 (3.0)
Introduction of a biologic agent10 (23.8)1 (4.2)3 (11.5)0 (0.0)
Intra-articular corticosteroid therapy18 (42.9)4 (16.7)9 (34.6)13 (39.4)
  • Values are number positive (%).