| Non-responders (n = 42) | 30% Responders (n = 24) | 50% Responders (n = 26) | 70% Responders (n = 33) | |
| Increase⩾50% in methotrexate dose | 17 (40.5) | 10 (41.7) | 3 (11.5) | 5 (15.2) |
| Start or dosage increase of prednisone | 13 (31.0) | 4 (16.7) | 3 (11.5) | 3 (9.1) |
| Introduction of a further second line agent | 8 (19.0) | 4 (16.7) | 4 (15.4) | 1 (3.0) |
| Introduction of a biologic agent | 10 (23.8) | 1 (4.2) | 3 (11.5) | 0 (0.0) |
| Intra-articular corticosteroid therapy | 18 (42.9) | 4 (16.7) | 9 (34.6) | 13 (39.4) |
Values are number positive (%).