Table 1 Allele and genotype frequencies of rs907715 (A/G) and rs2221903 (A/G) in European–American and African–American systemic lupus erythematosus (SLE) patients and controls
European–AmericanAfrican–American
Cases (644), n (%)Controls (644), n (%)OR (95% CI)p ValueCases (366), n (%)Controls (366), n (%)OR (95% CI)p Value
rs907715
Allele:
    A415 (32.2)490 (38.0)268 (36.6)293 (40.0)
    G873 (67.8)798 (62.0)1.29 (1.10–1.52)0.002464 (63.4)439 (60.0)1.16 (0.94–1.43)0.18
Genotype:
    AA67 (10.4)93 (14.4)49 (13.4)61 (16.7)
    AG281 (43.6)304 (47.2)170 (46.5)171 (46.7)
    GG296 (46.0)247 (38.4)1.66* (1.16–2.38)0.005147 (40.2)134 (36.6)1.37* (0.88–2.13)0.17
    HWE (p exact)110.661
rs2221903
Allele:
    A876 (68.0)923 (71.7)663 (90.6)688 (94.0)
    G412 (32.0)365 (28.3)1.19 (1.01–1.41)0.04469 (9.4)44 (6.0)1.63 (1.10–2.41)0.014
Genotype:
    AA298 (46.3)324 (50.3)303 (82.8)324 (88.5)
    AG280 (43.5)275 (42.7)57 (15.6)40 (10.9)
    GG66 (10.2)45 (7.0)1.60* (1.06–2.40)0.0256 (1.6)2 (0.0055)3.21* (0.64–16.02)0.13
    HWE (p exact)0.2110.380.12
  • *GG vs AA in cases versus controls.

  • OR, odds ratio; HWE, Hardy–Weinberg equilibrium.