| European–American | African–American | |||||||
| Cases (644), n (%) | Controls (644), n (%) | OR (95% CI) | p Value | Cases (366), n (%) | Controls (366), n (%) | OR (95% CI) | p Value | |
| rs907715 | ||||||||
| Allele: | ||||||||
| A | 415 (32.2) | 490 (38.0) | 268 (36.6) | 293 (40.0) | ||||
| G | 873 (67.8) | 798 (62.0) | 1.29 (1.10–1.52) | 0.002 | 464 (63.4) | 439 (60.0) | 1.16 (0.94–1.43) | 0.18 |
| Genotype: | ||||||||
| AA | 67 (10.4) | 93 (14.4) | 49 (13.4) | 61 (16.7) | ||||
| AG | 281 (43.6) | 304 (47.2) | 170 (46.5) | 171 (46.7) | ||||
| GG | 296 (46.0) | 247 (38.4) | 1.66* (1.16–2.38) | 0.005 | 147 (40.2) | 134 (36.6) | 1.37* (0.88–2.13) | 0.17 |
| HWE (p exact) | 1 | 1 | 0.66 | 1 | ||||
| rs2221903 | ||||||||
| Allele: | ||||||||
| A | 876 (68.0) | 923 (71.7) | 663 (90.6) | 688 (94.0) | ||||
| G | 412 (32.0) | 365 (28.3) | 1.19 (1.01–1.41) | 0.044 | 69 (9.4) | 44 (6.0) | 1.63 (1.10–2.41) | 0.014 |
| Genotype: | ||||||||
| AA | 298 (46.3) | 324 (50.3) | 303 (82.8) | 324 (88.5) | ||||
| AG | 280 (43.5) | 275 (42.7) | 57 (15.6) | 40 (10.9) | ||||
| GG | 66 (10.2) | 45 (7.0) | 1.60* (1.06–2.40) | 0.025 | 6 (1.6) | 2 (0.0055) | 3.21* (0.64–16.02) | 0.13 |
| HWE (p exact) | 0.21 | 1 | 0.38 | 0.12 | ||||
*GG vs AA in cases versus controls.
OR, odds ratio; HWE, Hardy–Weinberg equilibrium.