Table 2 Biological processes associated with responsiveness to treatment with anti-TNFα
Biological processNo. of genesp Value
Up-regulated in responders:
    Immunity and defence718<0.001
    T-cell mediated immunity111<0.001
    Cell surface receptor mediated signal transduction700<0.001
    MHCII-mediated immunity15<0.001
    Cell adhesion3400.0016
    Cytokine and chemokine mediated signalling pathway1260.0030
    Cell adhesion-mediated signalling1960.0056
    Signal transduction16620.016
    Macrophage-mediated immunity650.026
Up-regulated in non-responders:
    Protein biosynthesis2080.011

  • MHCII, major histocompatibility complex II.