Intervention | Total no. | No. omitted | No. included | Quality of studies included | Reasons for excluding |
Analgesics | |||||
Systemic | 6 | 3 | 3 | 2 = 1, 1 = 2 (crossover) | 1 = too few subjects, 2 = no control |
Topical | 3 | 1 | 2 | Both = 1 | No control+combined FMS and MFP |
Antidepressants | |||||
Tricyclic antidepressants | 8 | 2 | 6 | 4 = 1, 2 = 2 (crossover) | Single blind |
Selective serotonin reuptake inhibitors | 5 | 1 | 4 | 3 = 1, 1 = 2 (crossover) | No control |
Dual reuptake inhibitors | 5 | 2 | 3 | All = 1 | No control |
5HT2/3 Antagonists | 10 | 6 | 4 | 3 = 1, 1 = 2 (crossover) | No control |
Monoamine oxidase inhibitors | 4 | 2 | 2 | Both = 1 | 1 = data not clear, 1 = quasi randomised, single blind |
Others | |||||
Triiodothyronine | 3 | 0 | 3 | ||
Individuals | 16 | 4 | 12 | 5 = 1, 4 = 2, 3 = 5 | No results |
Exercise | |||||
Pool-based | 2 | 0 | 2 | 1 = 3, 1 = 4 | – |
Aerobic | 11 | 1 | 10 | 4 = 3, 6 = 4 | No results |
Strength | 4 | 1 | 3 | 1 = 3, 2 = 4 | Open, not randomised |
Mixed | 4 | 3 | 1 | 4 | 2 = open not randomised, 1 = no data |
Education/CBT | |||||
Education | 2 | 0 | 2 | 4 | – |
Education+exercise | 8 | 1 | 7 | 1 = 3, 7 = 4 | No control |
CBT | 2 | 0 | 2 | 5 | – |
CBT+exercise | 5 | 2 | 3 | 1 = 3, 2 = 4 | Open, not randomised |
Combination | 8 | 8 | 0 | Low quality and limited data | |
Dietary | 7 | 3 | 4 | 1 = 1, 1 = 4, 2 = 5 | No data |
Others | |||||
Physiotherapy | 4 | 2 | 2 | 1 = 3, 1 = 4 | No data and no control |
Balneotherapy | 4 | 0 | 4 | All = 4 | – |
Laser/light | 2 | 0 | 2 | Both = 3 | – |
Acupuncture | 4 | 1 | 3 | 1 = 1, 1 = 3, 1 = 4 | No data |
Magnets | 2 | 0 | 2 | Both = 1 | – |
Homeopathy | 3 | 3 | 0 | – | No data |
Individuals | 14 | 3 | 11 | 2 = 1, 1 = 3, 3 = 4, 3 = 5 | No data |
CBT, cognitive behavioural therapy; FMS, fibromyalgia syndrome; MFP myofascial pain.