Table 2 Breakdown of the short-listed studies to base recommendations on, and those eliminated from further analysis
InterventionTotal no.No. omittedNo. includedQuality of studies includedReasons for excluding
Analgesics
    Systemic6332 = 1, 1 = 2 (crossover)1 = too few subjects, 2 = no control
    Topical312Both  = 1No control+combined FMS and MFP
Antidepressants
    Tricyclic antidepressants8264 = 1, 2 = 2 (crossover)Single blind
    Selective serotonin reuptake inhibitors5143 = 1, 1 = 2 (crossover)No control
    Dual reuptake inhibitors523All = 1No control
    5HT2/3 Antagonists10643 = 1, 1 = 2 (crossover)No control
    Monoamine oxidase inhibitors422Both = 11 = data not clear, 1 = quasi randomised, single blind
Others
    Triiodothyronine303
    Individuals164125 = 1, 4 = 2, 3 = 5No results
Exercise
    Pool-based2021 = 3, 1 = 4
    Aerobic111104 = 3, 6 = 4No results
    Strength4131 = 3, 2 = 4Open, not randomised
    Mixed43142 = open not randomised, 1 = no data
Education/CBT
    Education2024
    Education+exercise8171 = 3, 7 = 4No control
    CBT2025
    CBT+exercise5231 = 3, 2 = 4Open, not randomised
    Combination880 Low quality and limited data
Dietary7341 = 1, 1 = 4, 2 = 5No data
Others
    Physiotherapy4221 = 3, 1 = 4No data and no control
    Balneotherapy404All = 4
    Laser/light202Both = 3
    Acupuncture4131 = 1, 1 = 3, 1 = 4No data
    Magnets202Both = 1
    Homeopathy330No data
    Individuals143112 = 1, 1 = 3, 3 = 4, 3 = 5No data
  • CBT, cognitive behavioural therapy; FMS, fibromyalgia syndrome; MFP myofascial pain.