Table 6 Baseline BML and change of BML and their relation to cartilage loss on the BLOKS and WORMS scales in the medial TF compartment
Adjusting for age, sex, BMIAdjusting for age, sex, BMI, alignment
Baseline BMLChange of BMLBaseline BMLChange of BML
Betap ValueBetap ValueBetap ValueBetap Value
WORMS scale1.5 (0.9, 2.1)<0.0010.8 (−0.4, 1.9)0.200.8 (0.1, 1.5)0.020.1 (−0.6, 0.9)0.72
BLOKS scale3.0 (1.8, 4.2)<0.0010.9 (−0.8, 2.6)0.311.8 (0.9, 2.8)<0.0010.8 (−0.4, 2.1)0.18
BLOKS scale, max baseline BML (area 0–2 (n = 37))7.1 (4.3, 9.9)<0.0010.9 (−2.0, 3.9)0.545.0 (1.5, 8.4)0.0010.8 (−2.1, 3.6)0.60
BLOKS scale, max baseline BML (area 3 (n = 16))1.7 (−0.4, 3.8)0.111.3 (−0.4, 3.1)0.142.2 (0.9, 3.5)0.0010.8 (−0.3, 1.9)0.16
BLOKS scale, max baseline BML (% of lesion 0–2 (n = 36))7.7 (4.6, 10.7)<0.0010.7 (−2.4, 3.8)0.675.2 (1.5, 8.9)0.0060.6 (−2.4, 3.5)0.71
BLOKS scale, max baseline BML (% of lesion 3 (n = 17))1.7 (−0.3, 3.8)0.091.4 (−0.3, 3.0)0.112.1 (0.7, 3.4)0.0021.0 (0.1, 2.0)0.03
  • BLOKS, Boston–Leeds Osteoarthritis Knee Score; BMI, body mass index; BML, bone marrow lesion; TF, tibiofemoral; WORMS, Whole Organ MRI Score.