Table 1 American College of Rheumatology 70% improvement (ACR70) responses obtained with active medication plus methotrexate or placebo plus methotrexate at 6 months in the indicated clinical trials

Agents	MTX-IR	Anti-TNF-IR	Reference(s)
Abatacept/placebo	20/7	10/2	Genovese et al, Kremer et al6 21
Rituximab/placebo	20/5	12/1	Cohen et al, Emery et al7 22
Tocilizumab/placebo	22/2	12/1	Emery at al, Smolen et al11 13
Adalimumab/placebo	21/3	ND	Keystone et al23
Etanercept/placebo	15/0	ND	Weinblatt et al24
Infliximab/placebo	18*/2	ND	Lipsky et al25

*Mean value of all active therapy arms.
IR, insufficient response; MTX, methotrexate; ND, not determined; TNF, tumour necrosis factor.