Table 1 American College of Rheumatology 70% improvement (ACR70) responses obtained with active medication plus methotrexate or placebo plus methotrexate at 6 months in the indicated clinical trials
Abatacept/placebo20/710/2Genovese et al, Kremer et al6 21
Rituximab/placebo20/512/1Cohen et al, Emery et al7 22
Tocilizumab/placebo22/212/1Emery at al, Smolen et al11 13
Adalimumab/placebo21/3NDKeystone et al23
Etanercept/placebo15/0NDWeinblatt et al24
Infliximab/placebo18*/2NDLipsky et al25
  • *Mean value of all active therapy arms.

  • IR, insufficient response; MTX, methotrexate; ND, not determined; TNF, tumour necrosis factor.