RA1 (n = 237) | RA2 (n = 177) | |||||
Anti-hPAD4+ | Anti-hPAD4– | p Value | Anti-hPAD4+ | Anti-hPAD4– | p Value | |
Female sex (%) | 71 | 74 | 0.606 | 89 | 80 | 0.209 |
Age of onset | 49 (13) | 50 (13) | 0.611 | 55 (12) | 56 (10) | 0.509 |
Disease duration | 2.7 (1.2) | 2.2 (1.1) | 0.006 | 15.7 (10.2) | 12.8 (9.7) | 0.092 |
CRP (mg/litre) | 9 (3 to 20) | 5 (2 to 11) | 0.007 | 17 (7 to 26) | 12 (7 to 20) | 0.033 |
Anti-CCP+ (%) | 80 | 55 | 0.001 | 82 | 59 | 0.005 |
RF+ (%) | 71 | 48 | 0.004 | 68 | 49 | 0.023 |
MHAQ score | NA | NA | NA | 2.0 (1.8 to 2.4) | 1.9 (1.6 to 2.0) | 0.008 |
Swollen joints | NA | NA | NA | 12.0 (7.1) | 9.2 (5.6) | 0.019 |
Tender joints | NA | NA | NA | 9.8 (7.2) | 9.4 (7.1) | 0.732 |
Deformed joints | NA | NA | NA | 4.8 (4.7) | 2.6 (4.0) | 0.009 |
Age of onset and disease duration are given in years. Categorical variables are given in percent, CRP levels and MHAQ scores are given in median (interquartile range) and other continuous variables are given in mean (SD).
CCP, cyclic citrullinated peptide; CRP, C-reactive protein; MHAQ, Modified Health Assessment Questionnaire; NA, not available; RF, rheumatoid factor.