| SoJIA (n = 20) | AoSD (n = 15) | |||||
| At anakinra onset | Last visit* on anakinra | p Value | At anakinra onset | Last visit* on anakinra | p Value | |
| Tender joint count | 20.5 (14.7) | 9.9 (22.5) | 0.02 | 8.5 (5.9) | 1.5 (2.7) | 0.0002 |
| Swollen joint count | 18.1 (15.1) | 10.7 (19.7) | 0.01 | 5.9 (5.8) | 0.9 (1.5) | 0.0005 |
| Assessment of pain (0–10 VAS)† | 4.4 (3.0) | 4.1 (34.3) | 0.3‡ | 6.6 (2.2) | 1.8 (2.5) | 0.0002‡ |
| Global assessment of disease activity (0–10 VAS)† | 4.1 (3.3) | 3.5 (31.9) | 0.16‡ | 7 (1.9) | 1.7 (2.3) | 0.0005‡ |
| Physician global assessment of disease activity (0–10 VAS) | 4.3 (2.6) | 3.8 (30.6) | 0.02‡ | 6.9 (2) | 2 (2.3) | 0.002‡ |
| ESR, mm/h | 51.9 (28.8) | 24.4 (20.2) | <0.0001 | 74 (33.5) | 22.1 (24.6) | 0.0005 |
| CRP, mg/litre | 78.9 (42.3) | 25.5 (29.9) | 0.0006 | 91.9 (71.8) | 16.6 (20.6) | 0.001 |
| Ferritinaemia, ng/ml | 2672 (5640) | ND | 997 (1410) | 283 (419) | 0.094 | |
| Leukocyte counts‡ (109/litre) | 15.4 (4.7) | 10.7 (4.2) | 0.004‡ | 11.9 (6.1) | 7.5 (2.3) | 0.017‡ |
| CHAQ | 1.4 (1.0) | 0.6 (1.0) | 0.01 | ND | ND | ND |
| Corticosteroid doses | 0.50 (0.32)§ | 0.24 (0.22)§ | 0.05 | 26.8 (20.1)§ | 8.6 (7.6) | 0.0047 |
Values indicated are mean (SD). Except where indicated otherwise, means of each variable before and after anakinra were compared by a non-parametric Wilcoxon test.
*Estimated by parents for SoJIA patients and by patient for AoSD patients.
‡Means were compared by t test. p Values <0.05 were considered significant.
†Latest follow-up: 14.7 (2–27) months in SoJIA patients and 14.3 (2–27) in AoSD patients.
§In mg/kg/day in SoJIA patients and in mg/day in AoSD patients.
AoSD, adult-onset Still disease; CHAQ, Childhood Health Assessment Questionnaire; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; SoJIA, systemic-onset juvenile idiopathic arthritis; VAS, visual analogue scale.