Table 1 Clinical characteristics of patients A and B, respectively
Age at diagnosis of SLE(years)SymptomsBaseline serology before rituximab treatmentPrevious immuno-suppressive therapyDuration of B-cell depletion(years)
30Fatigue, polyarthritis, Raynaud’s phenomenon, pleurisyAnti-SSA, anti-RNP, anti-dsDNA 570 IU/ml, IgM 1 g/l, IgG 15.9 g/l, CD19 0.04×109/lHydroxychloroquine, methotrexate, azathioprine, ciclosporin7.5
25Fever, myalgia, arthritis, serositis, haematological manifestationsAnti-SSA, anti-SSB, IgG aCL, IgM aCL, β1-GP, anti-dsDNA 100 IU/ml, IgM 4.4 g/l, IgG 13.4 g/l, CD19 not availableMethotrexate, azathioprine, ciclosporin A, cyclophosphamide5
  • aCL, anticardiolipin antibodies; β1-GP, β1-glycoprotein.