Table 2 Characteristics of the 12 subjects with positive anti-heparin–platelet factor 4 (HPF4) levels (OD 405⩾0.400)
PatientAge, sexIgG APhL (GPL units)IgM APhL (MPL units)IgG β2GP1 (SG units)IgM β2GP1 (SM units)anti-HPF4 (OD 405)SRAAPS events6
1. aPL+28, F25>802100.704+Digital infarcts
2. aPL+35, F24>802>800.407Second trimester miscarriage
3. aPL+50, F2422110.646Arteriovenous fistula thromboses
4. aPL+41, F77>8016>800.541Splenic infarcts
5. aPL+47, F15>803610.729Renal thrombotic microangiopathy
6. aPL+42, F3813350.591Cerebrovascular accident
7. aPL+40, F>8061>80780.740+Cerebrovascular accident
8. aPL–27, F1019240.606None
9. aPL–38, F1415220.408None
10. aPL–50, F75220.428None
11. aPL–21, M44330.500None
12. Control40, M18364110.650Unknown
  • aPL+, aPL-positive SLE; aPL–, aPL-negative SLE.

  • aPL, antiphospholipid antibodies; APS, antiphospholipid syndrome; SLE, systemic lupus erythaematosus; SG, standard IgG; SM, standard IgM; SRA, serotonin release assay.