Table 3 Overview of candidate genes located in RA susceptibility loci and differentially expressed in one or more RA expression studies with highest priority given to those genes found in properly powered studies.3 4 6 9
Gene IDGene locationGene nameLocus identified by RA linkage meta-analysisReferences
KNG13q27Kininogen 13q27.3–qterMaas et al,3 Liu et al,4 Lequerré et al9
CSF3R1p35–p34.3Colony stimulating factor 3 receptor1p35.3–p32.2Maas et al,3 Liu et al,4 Olsen et al6
TNNT21q32Troponin T type 21q32–q42.3Olsen et al6
PSMB96p21.3Proteasome subunit β type 9 (LPM2)6p21.3Lequerré et al9
EPS151p32EGF receptor pathway substrate 151p35.3–p32.2Lequerré et al9
MCP1q32Membrane cofactor protein (CD46)1q32–q42.3Lequerré et al9
EPB729q34.1Stomatin9q33.3–qterMaas et al3,
IRF-46p25–p23Interferon regulatory factor 46pter–p22.3Maas et al3,
NCF422q13.1Neutrophil cytosolic factor 422q13van der Pouw Kraan et al5
IL-84q13–q21Interleukin 84q13.3–q24van der Pouw Kraan et al5
GM-CSF (CSF2)22q13.1Colony stimulating factor 222q13van der Pouw Kraan et al5
STMN11p36.1Stathmin 1/oncoprotein 181p36van der Pouw Kraan et al5
PTPRK6q22.2–23.1Protein tyrosine phosphatase, receptor type, K6q23van der Pouw Kraan et al5
AA5988401p34.31p35–p32.2van der Pouw Kraan et al5
AA48759013q12–q1313q12van der Pouw Kraan et al5
HBACH (ACOT7)1p36.31–p36.11Acyl-coenzyme A thioesterase 71p36van der Pouw Kraan et al5