Table 2 Genes that show a differential expression in more than one study
Gene symbolGene nameChromosomal locationUp- or downregulated in RA compared with controls (or otherwise specified)Reference
CSTF2Cleavage stimulation factor, 3′ pre-RNA, subunit 2Xq22.1UpregulatedMaas et al,3 Olsen et al6
SLC genes (SLC7A7, SLC25A4)Solute carrier family7A7: 14q11.225A4: 4q35Upregulatedvan der Pouw Kraan et al,5 Yamada and Ymamoto14
CSF3RColony stimulating factor 3 receptor1p35–p34.3UpregulatedMaas et al,3 Olsen et al6
Troponin genes (TNNI1,TNNI2, TNNT2, TNNT3)Troponin 1, troponin 2,Troponin T2, troponin T3I1: 1q31.3I2: 11p15.5T2: 1q32–q42.3T3: 11p15.5Upregulatedvan der Pouw Kraan et al,5 Olsen et al6
ASLArgininosuccinate lyase7cen–q11.2DownregulatedMaas et al,3 Liu et al4
TP53Tumour protein p5317p13.1DownregulatedMaas et al,3 Liu et al4
TXKTXK tyrosine kinase4p12DownregulatedMaas et al,3 Liu et al4
LAMR1Ribosomal protein SA3p21.3DownregulatedOlsen et al,6 Lequerré et al9
BMP8Bone morphogenetic protein 81p35–p32DownregulatedMaas et al,3 Liu et al4
CYP3A4Cytochrome P450, family 3, subfamily A7q21.1Olsen et al:6 upregulatedOlsen et al,6 Lequerré et al9
Lequerré et al:9 downregulated in infliximab responders versus non-responders
KNG1Kininogen 13q27Maas et al3 and Liu et al:4 downregulated. Lequerré et al:9 upregulated in infliximab responders versus non-respondersMaas et al,3 Liu et al,4 Lequerré et al9
S100 genes (S100A10, S100A12)S100 calcium binding protein1q21Olsen et al:6 downregulatedBatliwalla et al:7 upregulatedOlsen et al,6 Batliwalla et al7
PPP2R3Protein phosphatase 2 (formerly 2A), regulatory subunit B”, α3q22.1Maas et al3 and Liu et al:4 downregulatedvan der Pouw Kraan et al:5 higher expressed in RA-II group compared with RA-I groupMaas et al,3 Liu et al4van der Pouw Kraan et al5
MMP-3Matrix metalloproteinase 311q22.3van der Pouw Kraan et al:5 higher expressed in RA-I group compared with RA-II group. Lindberg et al:10 upregulated in infliximab respondersvan der Pouw Kraan et al,5 Lindberg et al10