Table 1 Immunosuppressive therapies (other than prednisone) taken prior to the initiation of anti-tumour necrosis factor (TNF) therapy by the 25 patients with Takayasu arteritis (TAK)
AgentNo. (%)Duration of therapy* in months, median (range)Maximum dose, median (range)
Methotrexate22 (88)9 (1–144)20 mg/week (15–27.5)
Cyclophosphamide10 (40)6 (1–12)150 mg/day (50–150)†
Azathioprine5 (20)16 (1–48)150 mg/day
Mycophenolate mofetil3 (12)4 (1–4)2 g/day (2–3)
Ciclosporine A2 (8)3100 mg twice a day
Tacrolimus2 (8)46 mg/day
  • Where no range is provided, all patients received the agent in question at the same dose and/or for the same duration.

  • *Duration of therapy prior to the initiation of anti-TNF therapy. †One patient received monthly intravenous cyclophosphamide.