Relationship between anthropometric and body composition measures and tibial cartilage volume
| Univariate analysis (regression coefficient (95%CI)) | p Value | Multivariate analysis (regression coefficient (95%CI))* | p Value | Multivariate analysis (regression coefficient (95%CI))† | p Value | |
|---|---|---|---|---|---|---|
| *Change in tibial cartilage volume (mm3) per unit increase in the respective anthropometric and body composition measure after adjustment for age, gender and tibial plateau bone area in the regression equation. | ||||||
| †Change in tibial cartilage volume (mm3) per unit increase in the respective anthropometric and body composition measure after adjustment for fat-free mass and fat mass, ie, including age, gender, tibial plateau bone area, fat-free mass and fat mass in the regression equation. | ||||||
| ‡Adjusted for age, gender, tibial plateau bone area and respective baseline variable in the regression equation. | ||||||
| Variables at baseline (1990–4) | ||||||
| Weight (kg) | 49.6 (41.8 to 57.3) | <0.001 | 5.8 (−1.7 to 13.4) | 0.13 | – | |
| Body mass index (kg/m2) | 52.5 (19.4 to 85.5) | 0.002 | −2.9 (−22.7 to 16.9) | 0.77 | – | |
| Waist circumference (cm) | 45.0 (36.3 to 53.7) | <0.001 | −0.01 (−7.5 to 7.5) | 1.00 | – | |
| Waist-to-hip ratio (%) | 68.2 (56.9 to 79.4) | <0.001 | −2.0 (−13.8 to 9.9) | 0.74 | −3.7 (−16.9 to 9.6) | 0.59 |
| Fat-free mass (kg) | 92.8 (85.0 to 100.6) | <0.001 | 41.9 (22.7 to 61.1) | <0.001 | 48.4 (27.9 to 68.9) | <0.001 |
| Fat mass (kg) | 0.5 (−14.7 to 15.6) | 0.95 | −0.4 (−9.8 to 9.1) | 0.94 | −8.7 (−18.5 to 1.1) | 0.08 |
| Percentage of fat (%) | −57.0 (−71.1 to −42.9) | <0.001 | −7.2 (−18.8 to 4.5) | 0.23 | – | |
| Variables at current follow-up (2003–4) | ||||||
| Weight (kg) | 44.0 (36.5 to 51.4) | <0.001 | 6.7 (0.04 to 13.3) | 0.05 | – | |
| Body mass index (kg/m2) | 40.9 (11.0 to 70.8) | 0.01 | 3.1 (−14.4 to 20.6) | 0.73 | – | |
| Fat-free mass (kg) | 88.9 (81.2 to 96.6) | <0.001 | 42.6 (22.6 to 62.6) | <0.001 | 63.5 (39.3 to 87.6) | <0.001 |
| Fat mass (kg) | 5.5 (−10.3 to 21.3) | 0.49 | 0.3 (−8.9 to 9.5) | 0.95 | −15.9 (−26.6 to −5.3) | 0.004 |
| Change in the following variables | ||||||
| Weight (kg)‡ | 5.8 (−18.7 to 30.4) | 0.64 | 9.5 (−4.7 to 23.8) | 0.19 | – | |
| Body mass index (kg/m2)‡ | −5.2 (−73.7 to 63.3) | 0.88 | 25.1 (−14.7 to 64.9) | 0.22 | – | |
| Fat-free mass (kg)‡ | 53.4 (3.9 to 102.9) | 0.03 | 30.8 (2.7 to 58.9) | 0.03 | 60.8 (28.6 to 93.0) | <0.001 |
| Fat mass (kg)‡ | 7.4 (−25.3 to 40.2) | 0.66 | 8.9 (−9.1 to 26.9) | 0.33 | −1.5 (−18.8 to 15.9) | 0.87 |