Table 5

 Odds ratios for achieving a response at week 12 to adalimumab and various concomitant DMARDs compared with achieving a response to adalimumab and MTX alone after adjustment for baseline differences between groups

Concomitant DMARD groupMeasurement of response
ACR20ACR50ACR70Moderate EULARGood EULARDAS28<2.6
American College of Rheumatology 20% (ACR20), 50% (ACR50), and 70% (ACR70) improvement; AM, antimalarials; CsA, ciclosporin; DAS28, Disease Activity Score 28; DMARD, disease-modifying antirheumatic drug; EULAR, European League Against Rheumatism; LEF, leflunomide; MTX, methotrexate; SSZ, sulfasalazine.
Values are OR (95% CI), p value. ORs were calculated using the combination of adalimumab and MTX as the reference (OR  = 1.0).
*1 DMARD refers to a single concomitant DMARD other than MTX, LEF, SSZ, or AM.
No DMARDs0.52 (0.45 to 0.60), <0.00010.61 (0.53 to 0.70), <0.00010.74 (0.62 to 0.87), 0.00040.45 (0.38 to 0.53), <0.00010.53 (0.46 to 0.62), <0.00010.59 (0.49 to 0.71), <0.0001
LEF0.69 (0.58 to 0.82), <0.00010.72 (0.61 to 0.86), 0.00020.67 (0.54 to 0.84), 0.00060.68 (0.54 to 0.84), 0.00040.77 (0.64 to 0.93), 0.00580.75 (0.6 to 0.93), 0.0103
SSZ0.61 (0.41 to 0.89), 0.01120.76 (0.52 to 1.11), 0.15550.76 (0.46 to 1.26), 0.28170.72 (0.44 to 1.16), 0.17560.95 (0.63 to 1.43), 0.81421.51 (0.97 to 2.36), 0.0694
AM0.86 (0.58 to 1.26), 0.42921.14 (0.81 to 1.63), 0.45031.11 (0.73 to 1.68), 0.63970.81 (0.51 to 1.30), 0.38590.99 (0.67 to 1.44), 0.94201.03 (0.65 to 1.62), 0.9107
1 other DMARD*0.82 (0.49 to 1.37), 0.45150.92 (0.57 to 1.48), 0.72801.08 (0.61 to 1.94), 0.78710.79 (0.42 to 1.46), 0.44460.97 (0.57 to 1.65), 0.91570.93 (0.48 to 1.81), 0.8365
MTX+LEF0.67 (0.48 to 0.95), 0.02330.70 (0.50 to 0.97), 0.03070.72 (0.47 to 1.11), 0.13870.92 (0.59 to 1.45), 0.71830.72 (0.50 to 1.02), 0.06730.82 (0.53 to 1.25), 0.3491
MTX+AM1.01 (0.74 to 1.38), 0.94650.94 (0.72 to 1.23), 0.65900.89 (0.64 to 1.24), 0.48601.33 (0.87 to 2.03), 0.19220.99 (0.75 to 1.32), 0.94930.97 (0.69 to 1.34), 0.8310
MTX+SSZ1.01 (0.71 to 1.45), 0.94521.0 (0.73 to 1.36), 0.98220.99 (0.67 to 1.44), 0.94381.36 (0.82 to 2.24), 0.23660.94 (0.67 to 1.32), 0.73361.01 (0.68 to 1.48), 0.9729
MTX+SSZ+AM0.86 (0.51 to 1.45), 0.57080.97 (0.59 to 1.57), 0.88491.11 (0.62 to 2.0), 0.72082.89 (1.04 to 8.01), 0.04111.24 (0.74 to 2.09), 0.41801.61 (0.91 to 2.84), 0.1006