Table 4

 Observed adalimumab effectiveness at week 12

Patient groupDAS28*HAQ DI (0−3)*TJC (0−28)SJC (0−28)CRP (mg/l)
Absolute changePercentage changeAbsolute changePercentage changeAbsolute changePercentage changeAbsolute changePercentage changeAbsolute changePercentage change
AM, antimalarials; AZA, azathioprine; CRP, C-reactive protein; CsA, ciclosporin; DAS28, Disease Activity Score 28; DMARD, disease-modifying antirheumatic drug; HAQ DI, Health Assessment Questionnaire Disability Index; LEF, leflunomide; MTX, methotrexate; SJC, swollen joint count; SSZ, sulfasalazine; TJC, tender joint count.
Absolute change is given as mean (SD) or median.
*All changes in DAS28 and HAQ DI scores were significantly improved compared with baseline values (p⩽0.001).
†Of these 84 patients, 51% were receiving AZA, 27% were receiving parenteral gold, 17% were receiving CsA, and 5% were receiving penicillamine.
All patients (n = 6610)−2.1 (1.4)−35.4−0.54 (0.61)−34.0−8.0−73.3−6.0−72.7−5.5−44.4
Number of concomitant DMARDs
No DMARDs (n = 1731)−1.9 (1.4)−29.7−0.47 (0.63)−27.2−7.0−66.7−6.0−66.7−4.5−31.4
⩾1 DMARD (n = 4879)−2.2 (1.3)−37.3−0.56 (0.60)−36.4−8.0−75.0−6.0−75.0−5.7−47.8
1 DMARD (n = 4004)−2.2 (1.3)−37.2−0.56 (0.6)−36.3−8.0−75.0−6.0−75.0−5.5−47.3
2 DMARDs (n = 769)−2.3 (1.3)−38.0−0.56 (0.6)−36.8−8.0−75.0−6.0−75.0−7.0−50.5
⩾3 DMARDs (n = 106)−2.3 (1.3)−39.6−0.56 (0.57)−35.2−9.0−80.0−7.0−75.0−5.7−50.7
1 exclusive concomitant DMARD
MTX (n = 2794)−2.3 (1.3)−38.3−0.58 (0.6)−38.4−8.0−75.0−6.0−75.0−5.4−47.5
LEF (n = 842)−2.0 (1.3)−33.7−0.49 (0.59)−29.5−8.0−75.0−6.0−69.2−5.4−44.6
AM (n = 148)−2.4 (1.4)−37.9−0.72 (0.63)−46.0−9.0−75.0−7.0−79.2−8.1−52.3
SSZ (n = 133)−2.1 (1.3)−34.2−0.52 (0.62)−29.6−7.0−66.7−6.0−66.7−8.9−54.2
1 other DMARD† (n = 84)−2.2 (1.2)−35.1−0.55 (0.55)–27.1−8.0−72.1−7.0−68.4−9.7−49.2
DMARD combinations
MTX+LEF (n = 180)−2.2 (1.3)−36.4−0.54 (0.58)−36.3−9.0−76.9−7.0−78.9−6.0−46.2
MTX+AM (n = 269)−2.4 (1.3)−39.2−0.63 (0.66)−41.3−8.0−76.3−6.0−76.4−4.7−51.4
MTX+SSZ (n = 182)−2.4 (1.3)−39.8−0.55 (0.52)−38.8−8.0−76.4−6.0−75.0−10.1−56.7
MTX+SSZ+AM (n = 76)−2.4 (1.3)−40.7−0.58 (0.59)−37.6−7.0−80.0−7.0−75.8−7.8−55.2