Course of rheumatoid arthritis over 10 years
| Mean scores (SD) | Baseline | 1 year | 2 years | 5 years | 10 years | p‡ |
|---|---|---|---|---|---|---|
| (n = 149) | (n = 149) | (n = 145)* | (n = 137)† | (n = 149) | ||
| *Four of the 149 completers missed the 2 years data and †12 of the 149 completers missed the 5 years data. | ||||||
| ‡Repeated measures analyses of variance (ANOVA), p-values corrected with use of Simes’ procedure. | ||||||
| §9–15% missed hand radiographs the four first time points, only 1% missed hand radiographs at the 10-year examination. | ||||||
| Pain, global scores | ||||||
| Pain VAS(0–100) | 31.4 (24.5) | 28.7 (24.4) | 30.3 (24.4) | 29.6 (21.1) | 33.6 (23.2) | 0.99 |
| Pain AIMS(0–10) | 4.6 (2.4) | 4.3 (2.5) | 4.4 (2.5) | 4.6 (2.3) | 4.7 (2.4) | 0.99 |
| AIMS impact(0–10) | 3.8 (1.9) | 3.3 (2.3) | 3.6 (2.2) | 3.7 (2.1) | 3.9 (2.4) | 0.28 |
| Physician global(0–100) | – | – | 32.6 (20.4) | 16.1 (17.9) | 22.5 (16.4) | 0.01 |
| Psychosocial function | ||||||
| AIMS depression(0–10) | 2.0 (1.7) | 1.7 (1.5) | 1.8 (1.5) | 1.9 (1.6) | 2.0 (1.7) | 0.43 |
| AIMS anxiety(0–10) | 3.1 (2.1) | 2.7 (1.9) | 2.7 (1.9) | 2.9 (1.9) | 2.8 (2.0) | 0.96 |
| AIMS social activity(0–10) | 4.0 (1.7) | 3.7 (1.7) | 3.8 (1.9) | 3.7 (1.8) | 3.7 (1.8) | 0.07 |
| GHQ somatisation(0–21) | 7.5 (3.9) | 7.3 (4.3) | 7.2 (4.1) | 6.3 (3.7) | 6.1 (3.7) | 0.99 |
| GHQ depression(0–21) | 2.3 (3.4) | 2.0 (3.4) | 1.6 (2.7) | 2.0 (3.7) | 1.8 (3.2) | 0.004 |
| GHQ anxiety(0–21) | 6.7 (4.0) | 5.9 (4.4) | 6.3 (4.4) | 5.8 (4.6) | 5.3 (3.9) | 0.99 |
| GHQ social(0–21) | 8.0 (3.4) | 8.1 (3.3) | 8.2 (3.2) | 7.8 (2.8) | 8.1 (3.1) | 0.92 |
| GHQ-28(0–28) | 5.9 (6.0) | 5.6 (6.1) | 5.4 (6.0) | 4.8 (6.2) | 4.6 (5.8) | 0.21 |
| GHQ-28>11 (%) | 17.0 | 16.9 | 17.9 | 14.9 | 15.9 | |
| Physical function | ||||||
| HAQ (0–3) | 0.86 (0.61) | 0.85 (0.62) | 0.85 (0.65) | 0.86 (0.60) | 0.91 (0.70) | 0.03 |
| AIMS physical(0–10) | 1.8 (1.4) | 1.6 (1.2) | 1.8 (1.4) | 2.0 (1.3) | 2.1 (1.7) | 0.99 |
| Grip strength,average (kg) | 20.6 (12.2) | 20.5 (12.3) | 20.6 (12.8) | 20.0 (12.3) | 19.8 (11.7) | 0.99 |
| Disease activity | ||||||
| Ritchie articular index (0–78) | 9.16 (5.6) | 8.1 (6.3) | 8.5 (6.5) | 5.8 (6.3) | 13.0 (9.6) | 0.99 |
| Erythrocyte sedimentation rate | 25.3 (19.7) | 21.2 (15.0) | 19.8 (15.1) | 18.9 (15.1) | 17.8 (12.3) | 0.99 |
| C-reactive protein | 11.5 (16.5) | 8.0 (11.2) | 9.9 (12.0) | 12.6 (8.8) | 7.6 (8.7) | 0.99 |
| Radiographic damage | ||||||
| Modified Sharp(0–280)§ | 7.2 (12.7) | 10.8 (16.0) | 14.5 (18.9) | 24.7 (27.5) | 36.0 (36.6) | 0.02 |