Table 1

 Definitions of clinical states of ANCA-associated vasculitis used in EUVAS trials

Clinical subgroupDefinition
ANCA, antineutrophil cytoplasmic antibody; EUVAS, European Vasculitis study group.
LocalisedUpper and/or lower respiratory tract disease without any other systemic involvement or constitutional symptoms
Early systemicAny, without organ-threatening or life-threatening disease
GeneralisedRenal or other organ-threatening disease, serum creatinine <500 µmol/l
SevereRenal or other vital organ failure, serum creatinine >500 µmol/l
RefractoryProgressive disease unresponsive to glucocorticoids and cyclophosphamide