Definitions of clinical states of ANCA-associated vasculitis used in EUVAS trials
| Clinical subgroup | Definition | |
|---|---|---|
| ANCA, antineutrophil cytoplasmic antibody; EUVAS, European Vasculitis study group. | ||
| Localised | Upper and/or lower respiratory tract disease without any other systemic involvement or constitutional symptoms | |
| Early systemic | Any, without organ-threatening or life-threatening disease | |
| Generalised | Renal or other organ-threatening disease, serum creatinine <500 µmol/l | |
| Severe | Renal or other vital organ failure, serum creatinine >500 µmol/l | |
| Refractory | Progressive disease unresponsive to glucocorticoids and cyclophosphamide | |