Currently available cartilage and bone biomarkers
| Cartilage | Biomarker |
|---|---|
| Aggrecan | G1 (hyaluronan-binding-region), chondroitin sulphate region, chondroitin sulphate epitopes, keratan sulphate, aggrecanase cleavage neoepitopes, matrix metalloproteinase cleavage neoepitopes |
| Type II collagen | C-terminal propeptide, cross-links, collagenase cleavage neoepitopes |
| Other matrix molecules | Cartilage oligomeric matrix protein (thrombospondin 5), cartilage intermediate layer protein, matrilin-1 |
| Bone | |
| Type I collagen | N-procollagen and C-procollagen propeptides, N-telopeptides and C-telopeptides |
| Other matrix molecules | Osteocalcin, bone sialoprotein |