Mean S100A12 serum concentrations and expression of S100A12 in synovial tissue layers before and after treatment with intra-articular Corticosteroids (IAC) or infliximab
| Serum concentrations (ng/ml) | Lining layer | Sublining layer | Perivascular layer | Overall index | |
|---|---|---|---|---|---|
| *p<0.05; **p<0.005. | |||||
| IAC responder prior to IAC | 585 (±170) | 0.42 (±0.12) | 1.05 (±0.16) | 0.53 (±0.18) | 2.00 (±0.39) |
| After IAC | *490 (±160) | *0.11 (±0.07) | **0.37 (±0.18) | 0.32 (±0.13) | **0.79 (±0.35) |
| Infliximab responder prior to infliximab | 350 (±50) | 0.33 (±0.21) | 1.17 (±0.17) | 0.33 (±0.21) | 2.00 (±0.26) |
| After infliximab | **190 (±30) | 0 (±0) | *0.33 (±0.21) | 0 (±0) | *0.33 (±0.21) |
| Infliximab non-responder prior to infliximab | 650 (±180) | 0.25 (±0.16) | 1.25 (±0.25) | 0.88 (±0.23) | 2.38 (±0.53) |
| After infliximab | 620 (±150) | 0 (±0) | 0.75 (±0.25) | 0.38 (±0.26) | 1.13 (±0.44) |