Allelic and genotypic frequencies of two polymorphisms in the MHC2TA gene in Spanish patients and healthy controls
| MHC2TA rs3087456 | Patients with RA (n = 350) | Patients with MS (n = 396) | Patients with CD (n = 329) | Patients with UC (n = 361) | Controls (n = 519) |
|---|---|---|---|---|---|
| AA | 185 (52.8) | 203 (51.3) | 181 (55) | 203 (56.2) | 296 (57) |
| AG | 141 (40.3) | 168 (42.4) | 126 (38.3) | 139 (38.5) | 192 (37) |
| GG | 24 (6.8) | 25 (6.3) | 22 (6.7) | 19 (5.3) | 31 (6) |
| A | 511 (73) | 574 (72.5) | 488 (74.1) | 545 (75.5) | 784 (75.5) |
| G | 189 (27) | 218 (27.5) | 170 (25.8) | 177 (24.5) | 254 (24.5) |
| MHC2TA rs4774 | Patients with RA (n = 350) | Patients with MS (n = 396) | Patients with CD (n = 319) | Patients with UC (n = 344) | Controls (n = 509) |
|---|---|---|---|---|---|
| CD, Crohn’s disease; MS, multiple sclerosis; RA, rheumatoid arthritis; UC, ulcerative colitis. | |||||
| Values are n (%). | |||||
| GG | 210 (60) | 225 (56.8) | 188 (58.9) | 188 (54.7) | 284 (55.8) |
| GC | 119 (34) | 146 (36.8) | 109 (34.2) | 137 (39.8) | 192 (37.7) |
| CC | 21 (6) | 25 (6.3) | 22 (6.9) | 19 (5.5) | 33 (6.5) |
| G | 539 (77) | 596 (75.2) | 485 (76) | 513 (74.6) | 760 (74.7) |
| C | 161 (23) | 196 (24.7) | 153 (24) | 175 (25.4) | 258 (25.3) |