Table 2

 Gender-specific variations among SSc subsets

dcSScp (♂ vs ♀)lcSScp (♂ vs ♀)
MenWomenMenWomen
ACA, anticentromere autoantibody; ANA, antinuclear antibodies; dcSSc, diffuse cutaneous systemic sclerosis; lcSSc, limited cutaneous systemic scerosis; SSC, Systemic sclerosis; RO, onset of Raynaud’s phenomenon; ♂, male; ♀, female.
Number of patients2541094NA1801910NA
Age (years), mean (SD)52.7 (12.6)52.3 (14.0)0.6656.2 (13.2)57.5 (13.0)0.21
Age at RO (years), mean (SD)46.4 (13.4)42.1 (14.9)<0.00147.1 (14.9)42.5 (14.4)<0.001
Age at first non-RO (years), mean (SD)47.6 (13.1)44.1 (14.3)0.00149.0 (14.1)47.8 (13.3)0.26
Disease duration, years mean (SD)5.1 (5.0)7.9 (7.2)<0.0016.7 (5.7)9.8 (8.2)<0.001
Time between RO and first non-RO (years), mean (SD)1.4 (4.7)2.0 (5.6)0.102.0 (5.2)5.1 (8.7)<0.001
ANA positive93.7%93.0%0.7192.7%91.8%0.67
Scl-70 positive62.7%60.4%0.5131.3%22.8%0.02
ACA positive4.3%7.0%0.0826.3%50.3%<0.001