Table 3

Pathways which are overexpressed in all patients, and in the subgroups of IFN^high and IFN^low patients, all compared with healthy controls, analysed by gene set enrichment analysis

Pathway	No. of genes	All patients	IFN^high	IFN^low
		p Value	p Value	p Value
IFN, interferon; NS, nonsignificant.
Pathways are shown with a p value <0.05, and a false discovery rate value <0.25.
Type I IFN-induced genes²²	83	0.004	<0.001	NS
IFNα-induced²¹	36	0.022	<0.001	NS
IFNβ-induced²¹	51	NS	<0.001	NS
Cytokine–cytokine receptor interaction	129	0.006	0.005	NS
Neuroactive ligand–receptor interaction	90	0.009	NS	<0.001
Jak-STAT signalling pathway	86	0.016	0.008	NS
Complement and coagulation cascades	44	0.025	0.009	NS
Fatty acid metabolism	41	0.027	0.015	NS
IFNγ-induced²¹	34	NS	0.019	NS