Summary of linkage literature on hand osteoarthritis replicated in this study
| Chromosome number, map position (cM) | Nearest marker | LOD score | Phenotype | Sample | Reference |
|---|---|---|---|---|---|
| CMC, carpometacarpal; DIP, distal interphalangeal; IL1R1, interleukin 1 receptor, type 1; JSN, joint space narrowing; LOD, logarithmic odds ratio; OA, osteoarthritis; Tot-KL, Kellgren–Lawrence score for both hands. | |||||
| 1, 250 | D1S425–D2S2842 | 3.02 | Tot-KL | Community, UK | Present data |
| 1, 218 | Not available | 2.02 | DIP-OA | Community, US | 4 |
| 1, 202 | Not available | 3.03 | DIP-OA | Community, US | 4 (only females) |
| 1, 102 | D1S1665 | 2.96 | Total JSN score | Community, US | 6 |
| 19, 65 | D19S414–D19S418 | 4.26 | Tot-KL | Community, UK | Present data |
| 19, 52 | D19S433 | 1.82 | Total JSN score | Community, US | 6 |
| 19, 68 | D19S178 | 1.83 | Tot-KL | Community, US | 6 |
| 2, 90 | D2S136–D2S139 | 2.87 | DIP-OA | Community, UK | Present data |
| 2, 94.8 | D2S1566 | 2.20 | DIP-OA | Affected families; original mapping; Iceland | 3 |
| 2, 48 | D2S2168 | 2.44 | DIP-OA | Affected families; additional mapping; Iceland | 3 (additional markers) |
| 2, 48 | D2S2168 | 4.44 | DIP-OA and CMC-1 | Affected families; additional mapping; Iceland | 3 (additional markers) |
| 2, 51.5 | D2S405 | 2.23 | Total JSN score | Community, US | 6 |
| 2, 103.7 | Not available | 1.04 (p = 0.014) | DIP-OA | Affected families, UK | 18 |
| 2, 116 | IL1R1 (q shoulder) | p = 0.0001 | DIP-OA | Affected families, Finland | 17 |