Table 5 Theoretical framework of criteria which can be used to decide whether monitoring for specific AEs is useful

	No. needed to screen? (1/prevalence per year)	Severity? (Low/moderate/high)	Cost of screening? (Low/moderate/high)	Feasibility of scoring? (Low/moderate/high)
Body weight	1.5 6	Low	Low	High
Blood pressure	?	Moderate	Low	High
Peripheral oedema	?	Low	Low	High
Heart failure	?	High	Moderate	Moderate*
Dyslipidemia	?	Moderate	Moderate	Moderate*
Blood/urine glucose	12.5 6	Moderate	Moderate	High
Glaucoma	18.1 84	Moderate	Moderate	Moderate*

*Scoring in daily practice depends on presence of accurate laboratory tests and/or eye-pressure measurement equipment.