Test performance of modifications of the Berlin algorithm in the early spondyloarthritis clinic cohort with “fulfilment of Amor and European Spondylarthropathy Study Group criteria for spondyloarthritis” as gold standard
| Order of application | ||
|---|---|---|
| HLA-B27 first | MRI first | |
| AS, ankylosing spondylitis; HLA-B27, human leucocyte antigen B27; LR, likelihood ratio; MRI, magnetic resonance imaging; NPV, negative predictive value; PPV, positive predictive value. | ||
| LR-positive test, sensitivity/(1−specificity). | ||
| LR-negative test, (1−sensitivity)/specificity. | ||
| All patients (n = 68) | ||
| Sensitivity | 77% | 84% |
| Specificity | 56% | 72% |
| NPV | 74% | 72% |
| PPV | 69% | 84% |
| LR-positive test | 1.8 | 3.0 |
| LR-negative test | 0.41 | 0.22 |
| Only patients who are not fulfilling the modified New York criteria for AS (n = 54) | ||
| Sensitivity | 68% | 76% |
| Specificity | 70% | 72% |
| NPV | 56% | 72% |
| PPV | 79% | 76% |
| LR-positive test | 2.3 | 2.7 |
| LR-negative test | 0.46 | 0.33 |