Odds ratios describing the risk of RA associated with exposure to tobacco smoke among strata defined by specific genetic risk factors
| Genetic factor* | Case | Control | OR (95% CI) |
|---|---|---|---|
| *SE, shared epitope (includes HLA-DRB1*0101, *0102, *0401, *0404, *0405, *0408, *0413, *1001 and *1402 alleles); GSTM1, glutathione S-transferase M1. | |||
| SE positive | |||
| Non-smoker | 39 | 65 | 1 (reference) |
| Smoker | 24 | 44 | 0.91 (0.48 to 1.72) |
| SE negative | |||
| Non-smoker | 23 | 90 | 1 (reference) |
| Smoker | 18 | 39 | 1.81 (0.88 to 3.71) |
| GSTM1 null genotype | |||
| Non-smoker | 37 | 140 | 1 (reference) |
| Smoker | 21 | 60 | 1.32 (0.72 to 2.45) |
| GSTM1 present genotype | |||
| Non-smoker | 22 | 166 | 1 (reference) |
| Smoker | 27 | 97 | 2.10 (1.13 to 3.89) |