Table 2

‚ÄÉResults of conditional logistic regression analysis of associations of smoking, shared epitope positivity, and glutathione S-transferase M1 (GSTM1) null homozygosity with RA risk

Independent variableOR (95% CI)p Value
*SE positive alleles include HLA-DRB1*0101, *0102, *0401, *0404, *0405, *0408, *0413, *1001, and *1402.
Smoking6.0 (1.8 to 20.0)0.0036
Shared epitope (SE) positivity*4.6 (1.9 to 11.2)0.0006
GSTM1 null homozygosity3.4 (1.4 to 8.2)0.0074
Smoking-SE interaction0.2 (0.06 to 0.90)0.034
Smoking-GSTM1 null interaction0.3 (0.07 to 0.98)0.047