Table 1 Clinical details and observations of nerves and vessels breaching the tidemark in post-mortem cases
CaseAgeSexCause of deathHistory ofknee pain(+/–)Heberdensnodes(+/–)NSAIDusage(+/–)MankinscoreTidemarkbreach(+/–)PGPnerve(+/−)
175MMyocardial infarction and aneuryism+5
289MPulmonary oedema7
371MCerebrovascular accident++2
4 (both knees)77MAcute coronary syndrome5/9–/––/–
590MPneumonia+5
6 (both knees)88FCerebrovascular accident4/7+/–+/–
777MRectal tumour10
  • NSAID, non-steroidal anti-inflammatory drug; PGP, protein gene product.