Table 1 The frequency of the PTPN22 620W mutation in this study
Number of samplesPTPN22 allele number and frequencyp value
CT
BD total (n  =  270)52515 (2.8%)χ2  =  7.7, p  =  0.005
Con total (n  =  234)43830 (6.8%)OR  =  2.4 (1.2 to 4.7)
UK BD total (n  =  130)25010 (4%)χ2  =  6.0, p  =  0.001
UK Con (n  =  169)30830 (9.7%)OR  =  2.4 (1.1 to 5.4)
ME BD (n  =  140)2755 (1.8%)Fisher’s p  =  0.18
ME Con (n  =  65)1300 (0%)
UK BD [−AC/ME] (n  =  116)22210 (4.5%)χ2  =  4.4, p  =  0.04
UK Con (n  =  169)30830 (9.7%)OR  =  2.1 (1 to 4.7)
RV patients (n  =  136)24329 (11.9%)
UK Con (n  =  169)30830 (9.7%)χ2  =  0.5, p  =  0.45 (NS)
  • UK BD [−AC/ME] denotes the UK cohort with patients of Afro-Caribbean and Middle Eastern origin removed.