Table 4

 The associations between the age of symptom onset and HLA-DRB1 alleles and haplotypes, calculated using the quantitative transmission disequilibrium test (QTDT)

HLA allele or haplotypeDirection of associationMagnitude (years)p Value
The estimated magnitude of the reduction or increase of the age of onset associated with a particular allelic or haplotypic transmission is presented in column 3.
HLA-DRB1*08 alleleYounger age of symptom onset20.05
HLA-DRB1*03 alleleOlder age of symptom onset60.001
HLA-DRB1*13 alleleOlder age of symptom onset20.05
HLA-DRB1*03-non-B27 haplotypeOlder age of symptom onset60.006