Histological and immunohistochemical characterisation of the inflamed synovium in 12 patients with RA at baseline and at week 14
| Variable | Baseline | Week 14 | p Value |
|---|---|---|---|
| The synovial features were scored semiquantitatively on a 0–3 scale (0 is the lowest score and 3 is the highest score) and data are represented as median (range). The p values were calculated with Wilcoxon’s signed ranks test. | |||
| Lining layer thickness | 2 (1–3) | 1 (1–1.5) | 0.010 |
| Vascularity | 2 (1–3) | 1.25 (0.5–2.5) | 0.064 |
| Lymphoid aggregates | 0.5 (0–3) | 0 (0–1) | 0.040 |
| Inflammatory infiltration | 1.5 (0–3) | 1 (0–3) | 0.254 |
| Plasma cells | 0 (0–2.5) | 0.5 (0–2.5) | 0.518 |
| Polymorphonuclear cells | 0 (0–1) | 0 (0–15) | 0.157 |
| CD3+ T lymphocytes | 1 (0–3) | 1.5 (0–2) | 1.000 |
| CD4+ T lymphocytes | 0.5 (0–2.5) | 1 (0–1.5) | 0.773 |
| CD8+ T lymphocytes | 1 (0–2.5) | 1 (0–2.5) | 0.732 |
| CD20+ B lymphocytes | 1.5 (0–3) | 1.5 (0–2.5) | 0.226 |
| CD38+ plasma cells | 1 (0–3) | 1 (0–3) | 1.000 |
| Lining CD68+ macrophages | 1 (0.5–2) | 1 (0.5–2.5) | 0.332 |
| Sublining CD68+ macrophages | 1 (0.5–3) | 2 (0.5–3) | 0.066 |
| Lining CD163+ macrophages | 1.5 (0.5–3) | 1 (0.5–2.5) | 0.524 |
| Sublining CD163+ macrophages | 1 (0–2) | 1.25 (0–2.5) | 0.021 |
| CD1a+ dendritic cells | 1 (0–2.5) | 0.5 (0–3) | 0.832 |
| CD83+ dendritic cells | 0 (0–3) | 0 (0–2) | 0.131 |
| Lining ICAM-1 | 2 (1–3) | 2 (0.5–3) | 0.590 |
| Sublining ICAM-1 | 0.5 (0–3) | 1 (0–3) | 0.798 |
| Endothelial ICAM-1 | 2 (1.5–3) | 2.5 (0.5–3) | 0.952 |
| Endothelial E-selectin | 2 (2–3) | 2 (0–3) | 0.203 |
| Lining VCAM-1 | 1.5 (1–3) | 1.5 (0–2.5) | 0.298 |
| Sublining VCAM-1 | 0.5 (0–2) | 0.5 (0–2) | 0.831 |
| Endothelial VCAM-1 | 0 (0–1) | 0 (0–0.5) | 0.480 |
| Intracellular citrullinated proteins | 0 (0–2.5) | 0 (0–3) | 0.180 |
| HC gp-39 | 1 (0–2.5) | 0 (0–2.5) | 0.301 |
| mAb 12A staining | 0 (0–2) | 0 (0–3) | 0.276 |