Table 2 Case-control studies of myocardial infarction in patients receiving non-steroidal anti-inflammatory drugs (NSAIDs)
ExposureNumber of studiesNumber of participantsRandom-effects OR (95% CI)Fixed-effects OR (95% CI)
All NSAIDsAll studies14443 6411.17 (0.99 to 1.37)1.32 (1.29 to 1.35)
Large studies (>10 000 controls)11426 2321.34 (1.18 to 1.51)1.40 (1.37 to 1.43)
Small studies (<10 000 controls)317 4090.70 (0.39 to 1.27)0.61 (0.56 to 0.67)
European8326 4711.41 (1.25 to 1.59)1.50 (1.46 to 1.55)
North American6117 1700.91 (0.66 to 1.24)1.02 (0.98 to 1.06)
Matched controls6231 9221.40 (1.17 to 1.68)1.38 (1.33 to 1.42)
Unmatched controls8211 7191.01 (0.73 to 1.36)1.26 (1.22 to 1.30)
Industrial support664 5120.98 (0.66 to 1.43)1.05 (1.00 to 1.10)
No industrial support8379 1291.33 (1.14 to 1.55)1.41 (1.37 to 1.45)
Specific NSAIDsNaproxen11384 3241.03 (0.83 to 1.29)1.06 (1.00 to 1.13)
Ibuprofen8286 0891.08 (0.80 to 1.46)1.14 (1.09 to 1.19)
Diclofenac7260 7911.12 (0.68 to 1.87)1.07 (1.01 to 1.12)
Celecoxib7319 8411.01 (0.73 to 1.39)1.02 (0.94 to 1.10)
Rofecoxib7203 4871.19 (0.70 to 2.01)1.14 (1.05 to 1.24)