Table 3

 Short table of intraclonal diversification

Alignment of amino acid sequences of differently mutated offspring from six B lymphocyte clones of patients Nos 1, 4, 5, and 6 to their respective germline sequences. In the first line FR, CDR, and the respective amino acid positions are indicated. Amino acids that are identical to the germline sequence are symbolised by dashes.
CDR, complementarity determining region; FR, framework region.
--CDR1-- --CDR2 --CDR3
VH4-30 GGSISSGSYY...YIYYSGST...
J2_8-------D--...FM-----M...VRDLGLGSD
J2_12-D-----NF-...FM-----M...VRDLGLGSD
--CDR1-- --CDR2-- ------CDR3------
VH1-46: GYTFTSYYINPSGGST................
Ro85:------H----R--RPARVAGLAGHDNYYMDV
Ro89:----I-HD---R--RP----------------
--CDR1-- --CDR2-- -----------CDR3-----------
VH1-8:GYTFTSYDMNPNSGNT..........................
Ro101:----I-H-ID----K-ARDGKAISLTRGFHLSVEADYPGLDV
Ro151:--S-ITH--D-S--K---------------------------
--CDR1-- FR2->--CDR2-- -------CDR3-------
VH3-23:GFTFSSYAEWVSAISGSGGST..................
Ro113:------------D--------AKFQYYYGSRTPSNWFDP
Ro112:--S--TFG----D--------------------------
---CDR1--- FR2->-CDR2-- ----CDR3----
VH4-30:GGSISSGGYSEWIGYIYHSGST............
Ko152:-------L--------------ARGEGGSYDFDS
Ko155:-------L------E-N-----------------
--CDR1-- --CDR2-- -----CDR3-----
VH3-23:GFTFSSYAISGSGGST..............
Scy07:-L---T---R---DR-AKGTHSGSFSELDS
Scy64:-----D-W-NKD-SV---------------