Table 4

Estimated haplotype frequencies of subjects from the Rotterdam sample and the GARP study

Haplotype*	The Rotterdam study, ROA			The GARP study, CMC1 OA
	Controls†	No DD	DD‡	Total	Probands	Siblings
	(n = 809)	(n = 620)	(n = 163)	(n = 104)	(n = 57)	(n = 47)
*Haplotype frequencies ⩾0.01 in the following order: SNP3 (G>A), SNP5 (C>T), SNP6 (G>A) allowing missing genotype data.
†All subjects from the Rotterdam sample.
‡Subjects for whom no phenotypic data were available were excluded in the analysis.
¶p⩽0.01 v controls (no disc degeneration subjects).
§p⩽0.02 v controls.
CMC1, first carpometacarpal joint; DD, spinal disc degeneration; DIP, distal interphalangeal joint; GARP, Genetics, Osteoarthritis and Progression study; OA, osteoarthritis; ROA, radiographic osteoarthritis.
GCG	0.608	0.607	0.599	0.545	0.565	0.521
GCA	0.003	0.005	0.001	0.005	0.000	0.011
ACG	0.167	0.169	0.169	0.157	0.146	0.170
ACA	0.209	0.211	0.200	0.283§	0.280	0.287
ATG	0.014	0.009	0.031¶	0.010	0.009	0.011