Laboratory values and haemodynamic measures
| Variable | Before methotrexate | During methotrexate |
|---|---|---|
| Results are shown as mean (SD). | ||
| *p<0.01 for the effect of methotrexate. | ||
| SBP, systolic blood pressure; DBP, diastolic blood pressure. | ||
| ALT (U/l) | 20 (11) | 45 (24)* |
| Alkaline phosphatase(U/l) | 77 (17) | 75 (23) |
| Creatinine (μmol/l) | 88 (56) | 83 (46) |
| CRP (mg/l) | 24 (48) | 10 (15) |
| ESR (mm/1st h) | 15 (18) | 16 (22) |
| Haemoglobin (mmol/l) | 8.1 (0.8) | 7.7 (1.1) |
| Leucocytes (×109/l) | 7.8 (2.8) | 7.1 (2.4) |
| Thrombocytes (×109/l) | 253 (92) | 278 (88) |
| SBP (mm Hg) | 142 (20) | 139 (18) |
| DBP (mm Hg) | 70 (7) | 70 (9) |
| Heart rate (bpm) | 65 (12) | 66 (13 |
| Homocysteine (μmol/l) | 10.6 (4.1) | 14.9 (4.9)* |