Table 4

 Predictors of lymphoproliferative disease (n = 12) within the AECC group (n = 286)

Predictor variableTotal AECC cohort (No available)Lymphoma patients (No available)HR (95% CI)p Value
The analysis was performed using Cox regression with adjustment for age. *HR for one standard deviation (SD) increase. CD4+ (%) mean (SD) 43.32 (12.20), CD8+ (%) mean (SD) 28.59 (13.01), CD4+/CD8+ratio mean (SD)1.90 (1.18). †Owing to a U-shaped distribution for the risk of lymphoma, quartiles for C3, C4, and IgG were used, testing the risks for the highest and lowest quartiles versus the two middle ones. For all predictors the first ever assessment is used.
Age at diagnosis286121.02/yr (0.97 to 1.06)0.516
Salivary gland swelling (yes/no)81/1945/72.02 (0.62 to 6.61)0.247
Purpura/skin vasculitis (yes/no)29/2444/44.64 (1.13 to 16.45)0.017
ANA positivity (yes/no)240/4412/0
RF positivity (yes/no)156/1179/33.03 (0.80 to 11.24)0.102
SSA/SSB (yes/no)163/12010/22.58 (0.69 to 9.63)0.159
CD4-penia (yes/no)35/1308/38.14 (2.10 to 31.53)0.002
CD4+ (%)*165110.57 (0.34 to 0.93)0.026
CD8+ (%)*165111.76 (1.14 to 2.73)0.011
CD4+/CD8+ratio*165110.23 (0.07 to 0.73)0.013
CD4+/CD8+ratio ⩽ 0.8 (yes/no)29/1368/310.92 (2.8 to 41.83)0.000
C3 ⩽0.83 g/l†6086.18 (1.57 to 24.22)0.009
C3 = 0.84–1.12 g/l†11831.0 (referent)
C3 ⩾1.13 g/l†600
C4 ⩽0.18 g/l†6279.49 (1.94 to 46.54)0.006
C4 = 0.19–0.30 g/l†11621 (referent)
C4 ⩾0.31 g/l†6021.60 (0.22 to 11.42)0.641
IgG ⩽12.0 g/l†7131.41 (0.31 to 6.32)0.65
IgG = 12.1–21.4 g/l†13351 (referent)
IgG ⩾21.5 g/l †6852.54 (0.67 to 9.65)0.17