Larsen score at baseline and at two years in patients with early rheumatoid arthritis who were positive or negative for anti-CCP antibodies, IgG-RF, IgA-RF, or IgM-RF before symptoms of joint disease
| Pre-patient antibodies | ||||||||
|---|---|---|---|---|---|---|---|---|
| Anti-CCP | IgG-RF | IgA-RF | IgM-RF | |||||
| Pos | Neg | Pos | Neg | Pos | Neg | Pos | Neg | |
| Values are mean (SEM). | ||||||||
| *p<0.05 (positive compared with negative). | ||||||||
| nsNot significant (positive compared with negative). | ||||||||
| †Significance of the difference between baseline values compared with scores at two years. | ||||||||
| Anti-CCP, antibodies against cyclic citrullinated peptide; neg, negative; pos, positive; RF, rheumatoid factor. | ||||||||
| Baseline | 8 (1.5)* | 5 (0.7) | 6 (1.2)ns | 4 (0.7) | 5 (1.6) ns | 4 (0.8) | 7 (1.7)ns | 4 (0.7) |
| (n = 25) | (n = 58) | (n = 10) | (n = 52) | (n = 22) | (n = 40) | (n = 13) | (n = 49) | |
| 2 years | 14 (2.3)* | 9 (1.2) | 10 (2.3)ns | 10 (1.3) | 12 (2.0)ns | 9 (1.4) | 14 (3.0)ns | 9 (1.2) |
| (n = 19) | (n = 49) | (n = 10) | (n = 52) | (n = 22) | (n = 40) | (n = 13) | (n = 49) | |
| p Value† | <0.001 | <0.001 | <0.05 | <0.001 | <0.001 | <0.001 | <0.001 | <0.01 |