Mean, median, interquartile ranges, and minimum and maximum values of the different molecular markers at baseline in the 333 patients with all clinical variables recorded and all biological markers measured
| Markers* | Mean (SD) | Median | Interquartile ranges (25–75%) | Min–max |
|---|---|---|---|---|
| sMMP-1, matrix metalloproteinase-1; sMMP-3, matrix metalloproteinase-3; sCOMP, cartilage oligomeric matrix protein; sPINP, N-propeptides of collagen type I; sPIIINP, N-propeptides of collagen type III; sHA, hyaluronic acid; sCRP, C reactive protein; sYKL-40, Chondrex; uCTX-I, C-terminal crosslinking telopeptides of collagen type I; uCTX-II, C-terminal crosslinking telopeptides of collagen type II (s = serum; u = urine). | ||||
| sMMP-1 (ng/ml) | 6.34 (4.54) | 5.15 | 3.05–8.80 | 0.10–28.05 |
| sMMP-3 (ng/ml) | 25.1 (29.5) | 19.3 | 10.5–32.0 | 0.1–429.6 |
| sCOMP (U/l) | 10.7 (2.7) | 10.5 | 9.0–12.4 | 2.4–24.1 |
| sPINP (ng/ml) | 42.0 (18.4) | 40.9 | 28.2–51.0 | 0.2–139.5 |
| sPIIINP (ng/ml) | 4.28 (1.98) | 4.01 | 3.37–4.82 | 1.61–31.10 |
| sHA (mg/l) | 130 (102) | 98 | 63–160 | 21–750 |
| sCRP (mg/l) | 3.11 (4.73) | 1.60 | 0.80–3.30 | 0.10–41.30 |
| sYKL-40 (mg/l) | 83.8 (81.0) | 63.0 | 41.6–100.0 | 4.8–855.0 |
| uCTX-I (µg/mmol crea) | 186 (101) | 168 | 121–226 | 32–675 |
| uCTX-II (ng/mmol crea) | 321 (214) | 262 | 170–408 | 22–1262 |