Minimal important difference estimates for the skin score and Health Assessment Questionnaire—Disability Index
| Months | Mean (SD) skin score | Mean (SD) HAQ-DI | ||||||
|---|---|---|---|---|---|---|---|---|
| No change group | MID in the slightly improved group | Change in the moderately improved group | Change in the markedly improved group | No change group | MID in the slightly improved group | Change in the moderately improved group | Change in the markedly improved group | |
| HAQ-DI, Health Assessment Questionnaire—Disability Index; MID, minimally important difference. | ||||||||
| Negative score indicates improvement of the HAQ-DI and skin score. | ||||||||
| Effect size = mean difference from the baseline to month x, where x = 6, 12, and 24 months/SD at baseline. | ||||||||
| *Only 2 patients in this group. | ||||||||
| 6 | 1.5 (5.2)(n = 20) | −3.2 (4.3) (n = 32) | −6.9 (2.9)(n = 10) | * | 0.09 (0.4) (n = 20) | −0.10 (0.4) (n = 31) | −0.30 (0.3) (n = 10) | * |
| Effect size | 0.19 | 0.40 | 0.86 | 0.13 | 0.15 | 0.45 | ||
| 12 | 0.44 (5.6) (n = 16) | −1.5 (6.7) (n = 31) | −8.5 (5.1)(n = 24) | −12.5 (6.3)(n = 6) | 0.11 (0.4) (n = 16) | 0.03 (0.5) (n = 30) | −0.21 (0.43) (n = 24) | −0.35 (0.42) (n = 6) |
| Effect size | 0.06 | 0.19 | 1.06 | 1.56 | 0.17 | 0.05 | 0.32 | 0.53 |
| 18 | −0.7 (8.3) (n = 11) | −5.3 (6.6) (n = 20) | −7.2 (8.4)(n = 21) | −14.2 (5.1) (n = 12) | 0.01 (0.7) (n = 11) | −0.10 (0.5) (n = 20) | −0.09 (−0.55) (n = 21) | −0.55 (0.32) (n = 12) |
| Effect size | 0.09 | 0.66 | 0.90 | 1.77 | 0.01 | 0.15 | 0.13 | 0.83 |
| 24 | 1.1 (9.7)(n = 11) | −3.9 (6.9) (n = 10) | −8.9 (6.2)(n = 26) | −12.6 (5.9) (n = 16) | 0.03 (0.7) (n = 11) | −0.14 (0.6) (n = 10) | −0.24 (0.48) (n = 26) | −0.50 (0.27) (n = 15) |
| Effect size | 0.14 | 0.48 | 1.11 | 1.58 | 0.05 | 0.21 | 0.36 | 0.76 |