Cardiovascular events among subjects with and without rheumatoid arthritis, by age
| RA | No RA | Rate difference(95% CI) | Rate ratio (95% CI) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Events | Person-years | Rate | n | Events | Person-years | Rate | ||||
| CV, cardiovascular; MI, myocardial infarction; RA, rheumatoid arthritis. | |||||||||||
| The rate is events per 1000 person years. The rate difference is the absolute difference (excess) in events per 1000 people-years between patients with RA and those without RA. The composite outcome refers to MI, stroke or cardiovascular death. | |||||||||||
| All patients | 25 385 | 252 976 | |||||||||
| MI | — | 375 | 71 384 | 5.3 | — | 2022 | 709 166 | 2.9 | 2.4 (1.9–2.9) | 1.8 (1.7–2.0) | |
| Stroke | — | 363 | 71 260 | 5.1 | — | 1902 | 709 489 | 2.7 | 2.4 (2.0–2.9) | 1.9 (1.7–2.1) | |
| CV death | — | 437 | 71 912 | 6.1 | — | 3478 | 738 212 | 4.7 | 1.4 (0.9–1.9) | 1.3 (1.2–1.4) | |
| Any CV event | — | 1 042 | 70 612 | 14.8 | — | 6428 | 706 059 | 9.1 | 5.7 (4.9–6.4) | 1.6 (1.5–1.7) | |
| Age category (Any CV event) | |||||||||||
| 18–49 | 6873 | 35 | 19 900 | 1.8 | 68 754 | 109 | 201 873 | 0.5 | 1.2 (0.7–1.7) | 3.3 (2.4–4.5) | |
| 50–64 | 8178 | 175 | 23 473 | 7.5 | 80 617 | 784 | 232 648 | 3.4 | 4.1 (3.1–5.0) | 2.2 (1.9–2.5) | |
| 65–74 | 5664 | 309 | 15 735 | 19.6 | 56 990 | 1617 | 159 256 | 10.2 | 9.5 (7.6–11.3) | 1.9 (1.7–2.1) | |
| 75+ | 4488 | 623 | 11 414 | 54.6 | 46 615 | 3918 | 112 281 | 34.9 | 19.7 (16.0–23.4) | 1.6 (1.5–1.7) | |