Baseline immunohistological features of synovial tissue (n = 66 patients or knees)
| 90Y+GC (n = 37) | Placebo+GC (n = 29) | |
|---|---|---|
| FLS, fibroblast-like synoviocytes; GC, glucocorticoids; ICAM1, intercellular adhesion molecule 1; IL, interleukin; TNF, tumour necrosis factor; VCAM1, vascular cell adhesion molecule 1; 90Y, yttrium-90. | ||
| Values are mean (SD). | ||
| CD markers are expressed in cell counts/mm2, adhesion molecules and cytokines in integrated optical density/mm2. | ||
| No significant differences were seen in immunohistochemistry data of patients from both treatment groups (p>0.05). | ||
| Inflammatory cells | ||
| T cells | ||
| CD3 | 353 (338) | 361 (301) |
| CD4 | 37 (72) | 51 (9) |
| CD8 | 23 (54) | 24 (46) |
| Macrophages | ||
| CD68 lining | 524 (301) | 551 (317) |
| CD68 sublining | 349 (204) | 323 (174) |
| CD68 total | 822 (419) | 824 (379) |
| FLS | ||
| CD55 | 591 (364) | 582 (543) |
| B cells or plasma cells | ||
| CD22 | 16 (32) | 34 (98) |
| CD38 | 97 (142) | 123 (184) |
| Adhesion molecules | ||
| ICAM1 | 341 801 (178 814) | 347 259 (228 862) |
| VCAM1 | 57 009 (48 825) | 38 499 (38 733) |
| E-selectin | 158 706 (96 068) | 140 298 (82 230) |
| Pro-inflammatory cytokines | ||
| TNFα | 57 955 (52 426) | 60 211 (35 177) |
| IL1β | 67 100 (50 934) | 62 673 (44 601) |