SNP allele | Median (IQR) p value (Pc)* | ||||||
---|---|---|---|---|---|---|---|
Larsen 5† (n = 438) | SJC0† (n = 406) | SJC5† (n = 176) | TJC0† (n = 411) | TJC5† (n = 194) | HAQ0† (n = 378) | HAQ5† (n = 363) | |
Values are odds ratios and 95% confidence intervals. | |||||||
*p Value calculated using Mann–Whitney test; Pc = p value corrected for multiple testing. | |||||||
†Analysis adjusted using DMARD treatment by 5 years as a co-factor | |||||||
‡The PADI4 susceptibility haplotype, as defined in the Japanese population, was referred to as 2 and all other haplotypes as 1. | |||||||
HAQ0, HAQ score at baseline; HAQ5, HAQ score at five years; IQR, interquartile range; Larsen 5, Larsen score by five years; SJC0, swollen joint count at baseline; SJC5, swollen joint count at five years; SNP, single nucleotide polymorphism; TJC0, tender joint count at baseline; TJC5, tender joint count at five years. | |||||||
Padi4_89 | |||||||
G | 6 (0 to 20) | 6 (2 to 13) | 0 (0 to 2) | 7 (3 to 17) | 0 (0 to 4) | 0.75 (0.25 to 1.38) | 0.88 (0.25 to 1.63) |
A | 5 (0 to 22) | 6 (2 to 13) | 0 (0 to 2) | 8 (4 to 18) | 0 (0 to 3) | 0.875 (0.38 to 1.5) | 0.75 (0.25 to 1.75) |
Comparison | p = 0.57 | p = 0.33 | p = 0.36 | p = 0.41 | p = 0.22 | p = 0.03 (Pc = 0.60) | p = 0.28 |
Padi4_90 | |||||||
T | 5.5 (0 to 19) | 6 (2 to 13) | 0 (0 to 3) | 7 (3 to 17) | 0 (0 to 4) | 0.75 (0.25 to 1.38) | 0.815 (0.25 to 1.5) |
C | 5 (0 to 25) | 6 (2 to 13) | 0 (0 to 2) | 8 (4 to 19) | 0 (0 to 3) | 0.875 (0.38 to 1.5) | 0.815 (0.25 to 1.75) |
Comparison | p = 0.18 | p = 0.52 | p = 0.39 | p = 0.20 | p = 0.17 | p = 0.01 | p = 0.18 |
Padi4_92 | |||||||
G | 5 (0 to 19.5) | 6 (2 to 14) | 0 (0 to 2) | 8 (3 to 17) | 0 (0 to 4) | 0.75 (0.25 to 1.38) | 0.88 (0.25 to 1.5) |
C | 5 (0 to 24) | 6 (2 to 13) | 0 (0 to 2) | 8 (4 to 19) | 0 (0 to 4) | 0.875 (0.38 to 1.5) | 0.75 (0.25 to 1.75) |
Comparison | p = 0.24 | p = 0.28 | p = 0.93 | p = 0.26 | p = 0.46 | p = 0.04 (Pc = 0.80) | p = 0.48 |
Padi4_104 | |||||||
T | 5 (0 to 20) | 6 (2 to 13) | 0 (0 to 2) | 8 (3 to 17) | 0 (0 to 4) | 0.75 (0.25 to 1.38) | 0.88 (0.25 to 1.5) |
C | 5 (0 to 27) | 6 (2 to 14) | 0 (0 to 2) | 8 (4 to 19) | 0 (0 to 4) | 0.875 (0.38 to 1.5) | 0.88 (0.25 to 1.88) |
Comparison | p = 0.46 | p = 0.58 | p = 0.76 | p = 0.36 | p = 0.44 | p = 0.04 (Pc = 0.80) | p = 0.21 |
Haplotype‡ | |||||||
1 | 5 (0 to 19) | 6 (2 to 13) | 0 (0 to 2) | 7 (3 to 17) | 0 (0 to 4) | 0.75 (0.25 to 1.38) | 0.88 (0.25 to 1.5) |
2 | 5 (0 to 27) | 6 (2 to 14) | 0 (0 to 2) | 9 (4 to 19) | 0 (0 to 4) | 0.875 (0.38 to 1.5) | 0.88 (0.25 to 1.88) |
Comparison | p = 0.34 | p = 0.64 | p = 0.77 | p = 0.22 | p = 0.53 | p = 0.09 | p = 0.21 |