Table 2

 Association of PADI4 single nucleotide polymorphisms and haplotype with markers of disease activity and severity

SNP alleleMedian (IQR) p value (Pc)*
Larsen 5† (n = 438)SJC0† (n = 406)SJC5† (n = 176)TJC0† (n = 411)TJC5† (n = 194)HAQ0† (n = 378)HAQ5† (n = 363)
Values are odds ratios and 95% confidence intervals.
*p Value calculated using Mann–Whitney test; Pc  =  p value corrected for multiple testing.
†Analysis adjusted using DMARD treatment by 5 years as a co-factor
‡The PADI4 susceptibility haplotype, as defined in the Japanese population, was referred to as 2 and all other haplotypes as 1.
HAQ0, HAQ score at baseline; HAQ5, HAQ score at five years; IQR, interquartile range; Larsen 5, Larsen score by five years; SJC0, swollen joint count at baseline; SJC5, swollen joint count at five years; SNP, single nucleotide polymorphism; TJC0, tender joint count at baseline; TJC5, tender joint count at five years.
Padi4_89
G6 (0 to 20)6 (2 to 13)0 (0 to 2)7 (3 to 17)0 (0 to 4)0.75 (0.25 to 1.38)0.88 (0.25 to 1.63)
A5 (0 to 22)6 (2 to 13)0 (0 to 2)8 (4 to 18)0 (0 to 3)0.875 (0.38 to 1.5)0.75 (0.25 to 1.75)
Comparisonp = 0.57p = 0.33p = 0.36p = 0.41p = 0.22p = 0.03 (Pc = 0.60)p = 0.28
Padi4_90
T5.5 (0 to 19)6 (2 to 13)0 (0 to 3)7 (3 to 17)0 (0 to 4)0.75 (0.25 to 1.38)0.815 (0.25 to 1.5)
C5 (0 to 25)6 (2 to 13)0 (0 to 2)8 (4 to 19)0 (0 to 3)0.875 (0.38 to 1.5)0.815 (0.25 to 1.75)
Comparisonp = 0.18p = 0.52p = 0.39p = 0.20p = 0.17p = 0.01p = 0.18
Padi4_92
G5 (0 to 19.5)6 (2 to 14)0 (0 to 2)8 (3 to 17)0 (0 to 4)0.75 (0.25 to 1.38)0.88 (0.25 to 1.5)
C5 (0 to 24)6 (2 to 13)0 (0 to 2)8 (4 to 19)0 (0 to 4)0.875 (0.38 to 1.5)0.75 (0.25 to 1.75)
Comparisonp = 0.24p = 0.28p = 0.93p = 0.26p = 0.46p = 0.04 (Pc = 0.80)p = 0.48
Padi4_104
T5 (0 to 20)6 (2 to 13)0 (0 to 2)8 (3 to 17)0 (0 to 4)0.75 (0.25 to 1.38)0.88 (0.25 to 1.5)
C5 (0 to 27)6 (2 to 14)0 (0 to 2)8 (4 to 19)0 (0 to 4)0.875 (0.38 to 1.5)0.88 (0.25 to 1.88)
Comparisonp = 0.46p = 0.58p = 0.76p = 0.36p = 0.44p = 0.04 (Pc = 0.80)p = 0.21
Haplotype
15 (0 to 19)6 (2 to 13)0 (0 to 2)7 (3 to 17)0 (0 to 4)0.75 (0.25 to 1.38)0.88 (0.25 to 1.5)
25 (0 to 27)6 (2 to 14)0 (0 to 2)9 (4 to 19)0 (0 to 4)0.875 (0.38 to 1.5)0.88 (0.25 to 1.88)
Comparisonp = 0.34p = 0.64p = 0.77p = 0.22p = 0.53p = 0.09p = 0.21